Plant Transcription Factor Database
Previous version: v3.0
Citrus clementina
M-type_MADS Family
Species TF ID Description
Ciclev10003090mM-type_MADS family protein
Ciclev10003812mM-type_MADS family protein
Ciclev10006022mM-type_MADS family protein
Ciclev10006405mM-type_MADS family protein
Ciclev10006427mM-type_MADS family protein
Ciclev10006439mM-type_MADS family protein
Ciclev10006500mM-type_MADS family protein
Ciclev10006503mM-type_MADS family protein
Ciclev10006519mM-type_MADS family protein
Ciclev10006530mM-type_MADS family protein
Ciclev10006546mM-type_MADS family protein
Ciclev10006559mM-type_MADS family protein
Ciclev10006587mM-type_MADS family protein
Ciclev10006588mM-type_MADS family protein
Ciclev10006615mM-type_MADS family protein
Ciclev10006654mM-type_MADS family protein
Ciclev10006708mM-type_MADS family protein
Ciclev10006740mM-type_MADS family protein
Ciclev10006743mM-type_MADS family protein
Ciclev10006803mM-type_MADS family protein
Ciclev10006957mM-type_MADS family protein
Ciclev10006958mM-type_MADS family protein
Ciclev10007010mM-type_MADS family protein
Ciclev10007015mM-type_MADS family protein
Ciclev10007090mM-type_MADS family protein
Ciclev10007104mM-type_MADS family protein
Ciclev10009227mM-type_MADS family protein
Ciclev10009390mM-type_MADS family protein
Ciclev10010259mM-type_MADS family protein
Ciclev10010485mM-type_MADS family protein
Ciclev10012506mM-type_MADS family protein
Ciclev10013728mM-type_MADS family protein
Ciclev10013802mM-type_MADS family protein
Ciclev10013876mM-type_MADS family protein
Ciclev10017472mM-type_MADS family protein
Ciclev10018138mM-type_MADS family protein
Ciclev10020575mM-type_MADS family protein
Ciclev10020780mM-type_MADS family protein
Ciclev10022548mM-type_MADS family protein
Ciclev10023160mM-type_MADS family protein
Ciclev10023165mM-type_MADS family protein
Ciclev10023422mM-type_MADS family protein
Ciclev10024318mM-type_MADS family protein
Ciclev10024340mM-type_MADS family protein
Ciclev10024463mM-type_MADS family protein
Ciclev10027125mM-type_MADS family protein
Ciclev10027154mM-type_MADS family protein
Ciclev10027244mM-type_MADS family protein
Ciclev10029770mM-type_MADS family protein
Ciclev10029776mM-type_MADS family protein
Ciclev10030142mM-type_MADS family protein
Ciclev10030228mM-type_MADS family protein
Ciclev10030327mM-type_MADS family protein
Ciclev10030387mM-type_MADS family protein
Ciclev10031963mM-type_MADS family protein
Ciclev10032637mM-type_MADS family protein
Ciclev10033176mM-type_MADS family protein
Ciclev10033728mM-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513